Antisynthetase syndrome positive for anti-threonyl-tRNA synthetase (anti-PL7) antibodies.

نویسندگان

  • B Hervier
  • Y Uzunhan
  • E Hachulla
  • O Benveniste
  • H Nunes
  • P Delaval
  • L Musset
  • S Dubucquoi
  • B Wallaert
  • M Hamidou
چکیده

in circulating human monocytes is refractory to antibiotic treatment. Circulation 2001; 103: 351–356. 7 Boman J, Gaydos CA. Polymerase chain reaction detection of Chlamydia pneumoniae in circulating white blood cells. J Infect Dis 2000; 181: Suppl. 3, S452–S454. 8 Yamaguchi H, Yamada M, Uruma T, et al. Prevalence of viable Chlamydia pneumoniae in peripheral blood mononuclear cells of healthy blood donors. Transfusion 2004; 44: 1072–1078. 9 Boman J, Soderberg S, Forsberg J, et al. High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors. J Infect Dis 1998; 178: 274–277. 10 Hammerschlag MR, Chirgwin K, Roblin PM, et al. Persistent infection with Chlamydia pneumoniae following acute respiratory illness. Clin Infect Dis 1992; 14: 178–182. 11 Miyashita N, Niki Y, Nakajima M, et al. Prevalence of asymptomatic infection with Chlamydia pneumoniae in subjectively healthy adults. Chest 2001; 119: 1416–1419. 12 Blasi F, Damato S, Cosentini R, et al. Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment. Thorax 2002; 57: 672–676. 13 Wolf K, Fischer E, Hackstadt T. Degradation of Chlamydia pneumoniae by peripheral blood monocytic cells. Infect Immun 2005; 73: 4560–4570.

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New Insights into Antisynthetase Syndrome.

Antisynthetase syndrome (ASS) is a rare chronic autoimmune disorder (2-3 times more common in women than in men), associated with interstitial lung disease (the most important feature), dermatomyositis (DM), and polymyositis (PM). The cause of ASS is unknown. Recent developments in immunology have improved our knowledge and it is now possible to classify ASS according to the presence of myositi...

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Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.

Autoantibodies against several aminoacyl-transfer-RNA synthetases have been described in patients with myositis; anti-threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and compare them with previously reported cases. This multicenter study of patients positive for anti-PL-7, identified b...

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Anti-PL7 antisynthetase syndrome: A rare cause of autoimmune-mediated interstitial lung disease.

We present a case of anti-PL7 anti-synthetase syndrome (ASS), an autoimmune disease which should be considered in patients with interstitial lung disease or antibiotic resistant pneumonia when other more frequent diagnoses have been explored and ruled out, even in the absence of systemic autoimmune symptomatology. Our aim is to report a case of this rare syndrome and provide indications for pro...

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Mechanic’s hands in a woman with undifferentiated connective tissue disease and interstitial lung disease – anti-PL7 positive antisynthetase syndrome: a case report

INTRODUCTION Interstitial lung disease can be idiopathic or occur in the setting of connective tissue diseases. In the latter case it requires a different treatment approach with a better prognosis. Interstitial lung disease can precede the onset of typical connective tissue disease features by many years, and therefore meticulous multidisciplinary follow-up is crucial. This case highlights the...

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Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies.

OBJECTIVE The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. METHODS Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunopreci...

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عنوان ژورنال:
  • The European respiratory journal

دوره 37 3  شماره 

صفحات  -

تاریخ انتشار 2011